. 2015 Sep 30;10(9):e0138917. doi: 10.1371/journal.pone.0138917

Table 3. Effect of Xestospongia testudinaria methanolic extract (100 mg/kg) and indomethacin (10 mg/kg) on plasma TNF-α, IL-1β and IL-6 measured in carrageenan-induced rat hind paw edema.

Treatment regimen	TNF-α(pg/ml)	IL-1β (pg/ml)	IL-6 (pg/ml)
Control	309 ± 20	127 ± 36	129 ± 7
Carrageenan	402 ± 26 ^a	1529 ± 159 ^a	266 ± 21 ^a
Indomethacin	333 ± 33 ^b	1011 ± 106 ^b	131 ± 5 ^b
Xestospongia testudinaria extract	330 ± 17 ^b	1076 ± 61 ^b	124 ± 2 ^b

Data are mean ± SD (n = 6).

^aSignificant versus control (P ≤ 0.05).

^b Significant versus carrageenan (P ≤ 0.05).