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SelK may stabilize the acyl-DHHC6 intermediate in a manner that may not be dependent on the Sec residue. DHHC6 first interacts with palmitoyl-CoA and becomes autopalmitoylated on a Cys residue. On autopalmitoylation of the DHHC6 enzyme, SelK may stabilize the acyl-DHHC6 intermediate until the target protein can be palmitoylated. CoA, coenzyme A; Sec, selenocysteine.
