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SelK may enhance DHHC6-mediated protein palmitoylation by preventing PAT oligomerization. Formation of dimers or oligimers has been shown to occur for some PATs, and SelK may prevent DHHC6 oligomerization, thereby increasing the monomeric state of DHHC6 and increasing catalysis of the palmitoylation reaction. PAT, protein acyltransferase.
