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. 2015 Oct 1;23(10):761–774. doi: 10.1089/ars.2015.6277

FIG. 2.

FIG. 2.

Metabolic parameters of Scly KO mice on high-fat diet. (A) Fasting serum glucose levels of WT (n = 4) and Scly KO (n = 6) mice at 3 months of age. (B) Glucose tolerance test after a glucose overload with area under the curve (AUC) quantification plotted as bar graph; n = 11 per group. Test was performed after mice were fed for 3 months a high-fat diet. (C) Insulin tolerance test after glucose overload with AUC quantification plotted as bar graph; n = 3 per group. Test was performed after mice were fed for 3 months on a high-fat diet. (D) Plasma cholesterol levels at time of euthanasia (4 months after feeding of high-fat diet started), n = 6 per group. (E) Serum hydroxynonenal (HNE)-his adduct levels at time of euthanasia (4 months after feeding of high-fat diet started); n = 9 per group. Values are mean ± SEM; *p < 0.05, **p < 0.01, and ns, not significant, by Student's unpaired t-test with 95% confidence interval in (A), (D), (E), and AUC calculations of (B) and (C). Black bars and circles: WT mice; white bars and open circles: Scly KO mice.