FIG. 4.

Hepatic selenoprotein expression in Scly KO mice fed a high-fat diet. (A) GPx1, selenophosphate synthethase 2 (SPS2), and Seps1 protein expression measured by Western blot and normalized by beta-actin expression; n = 4–6 per group. (B) Total thioredoxin reductase activity; n = 6 per group. Values are mean ± SEM; ns, not significant. Averages between WT and Scly KO mice displayed in this figure were compared according to two-tailed Student's unpaired t-test with 95% confidence interval. Black bars: WT mice; white bars: Scly KO mice.