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. 2015 Oct 1;23(10):761–774. doi: 10.1089/ars.2015.6277

FIG. 5.

FIG. 5.

Hepatic energy metabolism in Scly KO mice fed a high-fat diet. (A) Pyruvate levels; n = 6. (B) Pyruvate carboxylase (Pcx) and pyruvate dehydrogenase (Pdh) expression; n = 6 per group. (C) Citrate synthase activity measured at time of euthanasia; n = 6 per group. (D) Acetyl-CoA carboxylase 1 (ACC1) protein levels. (E) Phosphorylated and total levels of AMP kinase alpha (AMPKalpha). Graph displays ratio of phosphorylated to total levels, all normalized by beta-actin levels; n = 4 per group. (F) Scavenger receptor SR-B1 protein levels; n = 6 per group. (G) Suppressor of cytokine signaling 3 (SOCS3) protein levels; n = 6 per group. Values are mean ± SEM, with *p < 0.05, **p < 0.01, ***p < 0.001, and ns, not significant by comparison with two-tailed Student's unpaired t-test with 95% confidence interval. Black bars: WT mice; white bars: Scly KO mice. a.u., arbitrary units.