Table 2. Major cardiovascular events in males.
(Data are n [%] patients unless indicated otherwise).
| Patient group (age range, years) | All DS (0–89) | All Non-DS (0–89) | DS (0–18) | Non-DS (0–18) | DS (19–50) | Non-DS (19–50) | DS (51+) | Non-DS (51+) |
|---|---|---|---|---|---|---|---|---|
| Sample size | 2,153 | 8,019 | 1,282 | 5,091 | 685 | 2,181 | 186 | 747 |
| Outcome Events | ||||||||
| Any cerebrovascular event | 47 (2.2) | 76 (1.0) *** | 11 (0.9) | 6 (0.1) *** | 11 (1.6) | 11 (0.5) ** | 25 (13.4) | 59 (7.9) * |
| Any stroke | 41 (1.9) | 61 (0.7) *** | 11 (0.9) | 6 (0.1) *** | 9 (1.3) | 10 (0.5) * | 21 (11.3) | 45 (6.0) * |
| Ischemic stroke | 17 (0.8) | 24 (0.3) ** | 7 (0.5) | 2 (0.04) *** | 4 (0.6) | 4 (0.2) | 6 (3.2) | 18 (2.4) |
| Hemorrhagic stroke | 16 (0.7) | 15 (0.2) *** | 5 (0.4) | 2 (0.04) ** | 4 (0.6) | 6 (0.3) | 7 (3.8) | 7 (0.9)* |
| Any coronary event | 31 (1.4) | 201 (2.5) ** | 1 (0.1) | 0 (0.0) | 11 (1.6) | 59 (2.7) | 19 (10.2) | 142 (19.0) ** |
| Myocardial infarction | 24 (1.1) | 187 (2.3) *** | 1 (0.1) | 0 (0.0) | 7 (1.0) | 53 (2.4) | 16 (8.6) | 134 (17.9) ** |
DS = Down syndrome.
Any cerebrovascular event includes stroke (ischemic, hemorrhagic or unspecified) or transient ischemic attack.
Any coronary event includes myocardial infarction or angina.
* P<0.05
** P<0.01
*** P<0.001 (McNemar test)—for comparing proportions between DS and non-DS groups