Table 1. Estimations of key parameters using either the STS or the mixed effects modeling approaches.
| DATA | METHOD | GROUP | VLDL1 FCR | VLDL1 FTR | VLDL1 FDCR | VLDL1 SR | VLDL1 pool | VLDL2 IndSR | VLDL2 FCR | VLDL2 DSR | VLDL2 pool | Delay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | ||||||||||||
| STS | Control | 12.68 (51) | 5.63 (44) | 6.05 (101) | 8.7 (44) | 0.69 (58) | 3.86 (54) | 5.31 (41) | 2.33 (34) | 1.21 (49) | 0.5 (27) | |
| STS | DM2 | 9 (55) | 4.6 (53) | 4 (82) | 13.13 (36)** | 1.46 (57)*** | 6.71 (42)** | 4.85 (48) | 2.38 (58) | 1.93 (42)** | 0.42 (16)* | |
| NLME | Control | 13.54 (46) | 4.82 (33) | 7.18 (115) | 9.3 (26) | 0.69 (56) | 3.31 (75) | 5.04 (23) | 2.51 (24) | 1.21 (50) | 0.47 (22) | |
| NLME | DM2 | 10.95 (41) | 6.27 (40)* | 4.27 (69)* | 16.08 (28)*** | 1.47 (54)*** | 9.21 (24)*** | 6.49 (32)* | 2.91 (49) | 1.92 (43)** | 0.38 (21)* | |
| Truncated | ||||||||||||
| STS | Control | 15.51 (50) | 7.04 (49) | 7.01 (100) | 11.27 (40)† | 0.73 (64) | 5.12 (68) | 6.94 (44)† | 2.81 (34) | 1.18 (50) | 0.49 (29) | |
| STS | DM2 | 11.15 (49) | 5.17 (76) | 5.16 (89) | 16.42 (52)* | 1.47 (57) ** | 7.61 (47) | 5.89 (45) | 2.98 (63) | 1.92 (45)** | 0.41 (22) | |
| NLME | Control | 13.94 (48) | 3.72 (38)† | 9.05 (87) | 10.11 (27) | 0.73 (60) | 2.7 (84) | 4.7 (17) | 2.56 (23) | 1.18 (52) | 0.47 (24) | |
| NLME | DM2 | 11.6 (49) | 4.55 (65)† | 5.98 (86) | 17.03 (29)*** | 1.47 (55)** | 6.69 (39)***,‡ | 5.26 (38) | 2.94 (49) | 1.93 (46)** | 0.36 (19)** | |
| Reduced | ||||||||||||
| STS | Control | 14.49 (66) | 4.58 (55) | 8.27 (117) | 9.95 (41) | 0.69 (58) | 3.14 (82) | 4.92 (37) | 2.3 (38) | 1.21 (49) | 0.5 (22) | |
| STS | DM2 | 10.5 (63) | 4.5 (37) | 5.39 (107) | 15.28 (52)* | 1.46 (57)*** | 6.55 (49)** | 4.99 (47) | 2.58 (88) | 1.93 (42)** | 0.43 (24) | |
| NLME | Control | 15.12 (51) | 5.03 (21) | 8.81 (103) | 10.37 (22) | 0.69 (56) | 3.45 (62) | 5.08 (20) | 2.5 (21) | 1.21 (49) | 0.5 (17) | |
| NLME | DM2 | 11.39 (40) | 6.11 (35) | 4.85 (70) | 16.67 (27)*** | 1.46 (53)*** | 8.94 (27)*** | 6.36 (30)* | 2.94 (53) | 1.92 (44)** | 0.4 (21)** |
Healthy control subjects (Control) and type 2 diabetic patients (DM2) are compared using the two approaches and using three sets of data: The complete data set (All), the truncated data set (up to 4 hours, Truncated), and the reduced data set (every second data point removed, Reduced). The estimated parameters are presented as geometric mean (coefficient of variation). Differences between Control and DM2 were compared using t-test after log-transforming the data. FCR, fractional catabolic rate; FTR, fractional transfer rate; FDCR, fractional direct catabolic rate; SR, secretion rate; indSR, in-direct secretion rate (ie flux from VLDL1), DSR, direct secretion rate.
*, p<0.05;
**, p<0.01;
***, p<0.001 (versus Control within same model and data set).
†, p<0.05,
‡, p<0.01 (versus All data within the same group and model).