Figure 2. Effects of TNF-α inhibition on macrophage recruitment and histological changes in Ins2Akita mice.
A) Immunohistochemical staining for Mac-2 positive macrophages in glomeruli and PAS-stained sections at 18 wk of age. Images are representative of 7-15 mice in each group. B) Summary data for macrophages/glomerulus. C) Summary data for glomerular PAS score. Data are presented as mean ± SEM. *p<0.01, **p<0.0001 compared to normal. Scale bar: 10 μm.