Table 1.

Effects of murine anti-TNF-α antibody on diabetic Ins2^Akita mice at 18 weeks of age.

Treatments	Normal	Ins2Akita + Vehicle	Ins2Akita + Anti-TNF-α	Ins2Akita + Captopril
Mouse number	16	7	7	7
BW (g)	26.4±0.6	22.1±1.1a	23.8±0.9a	23.2±0.4a
BG (mg/dL)	129±4	460±20d	451±25d	472±19d
HgbA1C %	5.5±0.07	12.7±0.2d	12.1±0.5d	12.2±0.5d
UV (ml/24 hrs)	0.96±0.2	4.22±0.9a	3.15±0.7	3.6±1.1
KW/BW (g/100 g BW)	0.96±0.03	1.27±0.06c	1.08±0.03e	1.25±0.08c
SBP (mmHg)	122±3	124±4	114±4	124±5
Fluid (%)	7.1±0.1	5.9±0.2b	5.8±0.1b	6.0±0.1b

Data are mean ± SEM.

^a: p<0.05,

^b: p<0.005,

^c: p<0.001,

^d: p<0.0001 compared to normal;

^e: p<0.05 compared to Ins2^Akita + vehicle.

BW: body weight, BG: blood glucose, HgbA1c: hemoglobin A1c, UV: urine volume, KW/BW: kidney weight/body weight, SBP: systolic blood pressure.