Table 2.

Effects of selective TNF-α depletion in macrophages after 12 weeks of diabetes.

	TNF αFlox/Flox		CD11 bCre/TNF-αFlox/Flox
Treatment	Normal	Diabetes	Normal	Diabetes
Mice number	7	11	11	12
Body Weight (g)	29.6±1.3	16.7±1.1a	33.1 ±0.5	23.1±0.8b,c
Blood glucose (mg/dL)	156±9.9	499±0.25a	149±7.0	490±5.4b
SBP (mmHg)	125±1.9	121±4.9	138±6.1	128±4.0
KW/BW (g/100 g BW)	0.625±0.029	1.139±0.028a	0.652±0.012	0.946±0.038b,c
% Fluid	7.03±0.21	5.73±0.11a	7.05±0.10	5.88±0.12b

Data are mean ± SEM.

^a: p<0.01 compared to normal TNF-α^Flox/Flox;

^b: p<0.01 compared to normal CD11b^Cre/TNF-α^Flox/Flox;

^c: p<0. 01 compared to diabetic TNF-α^Flox/Flox.

SBP: systolic blood pressure, KW/BW: kidney weight/body weight.