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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Kidney Int. 2015 Jul 22;88(4):699–710. doi: 10.1038/ki.2015.207

Figure 3. Structure and functions of PC1 and related polycystin-like proteins, plus PC2.

Figure 3

The Key shows the different domains and other motifs found in these proteins. PC2 is shown complexed with PC1 via PC2 CC2 and the PC1 coiled coil region. A high degree of similarity between PC1 paralogs is found in the transmembrane regions but with more variation in the N-terminal ectodomains and the cytoplasmic tails. The structure of PC2L1 and PC2L2 are similar to PC2 but PC2L2 does not have an EF-hand.