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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Kidney Int. 2015 Jul 22;88(4):699–710. doi: 10.1038/ki.2015.207

Figure 4. Models of the biosynthesis, maturation and trafficking of the polycystin complex.

Figure 4

PC1 (red) binds to PC2 (blue) shown as a putative dimer in the ER prior to undergoing GPS cleavage. At this stage, both proteins are expressed as EndoH-sensitive glycoforms (empty circles). EndoH-resistance (filled circles) is acquired with passage through the trans-Golgi with a small pool of an EndoH-resistant complex detectable in primary cilia. An alternative model proposes that EndoH-sensitive PC2 exits the cis-Golgi and traffics independently of PC1 which undergoes normal Golgi maturation, acquiring Endo H-resistance. The broken lines indicate other regulatory pathways which could determine the levels of both proteins, complex formation and subcellular localisation.