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. 2015 Sep 30;10(9):e0139252. doi: 10.1371/journal.pone.0139252

Table 3. Predictors of each QLQ-C30, QLQ-BR23, and SF-36 subscale after surgery over a 2-year period # .

QLQ-C30 QLQ-BR23 SF-36
Predictors GQOL PF RF EF CF SF BI SF SE FP PCS MCS
Time
 6th month vs. baseline 14.20** 20.03** 18.32** 24.69** 26.53** 10.05* 23.21** 10.24** 12.79** 17.54** 5.67** 5.07**
 1st year vs. baseline 19.04** 32.59** 30.82** 38.80** 36.28** 16.73** 35.43** 18.14** 26.61** 24.39** 9.89** 10.64**`
 2nd year vs. baseline 26.59** 46.69** 41.64** 44.01** 40.37** 24.36** 46.15** 19.97** 29.86** 31.36** 12.82** 11.69**
Surgical type
 MRM vs. BCS -1.49 -1.18 -3.76* -3.98** -5.15** 0.74 -5.39** 1.90 -0.20 0.43 -0.46 -2.48*
 TRAM vs. BCS 1.36 4.67* 2.62 5.86** 2.98 0.21 -2.95* 3.39* 3.24* 1.06 3.24* 3.49*
Age -0.23** -0.03 -0.02 -0.14* -0.02 -0.04 -0.42* -0.28** -0.29** -0.17* -0.07 -0.12*
CCI score -0.07* -0.08* -0.08* -0.10** -0.09* -0.03 -0.11** -0.09* -0.07* -0.09* -0.07* -0.10**
Tumor stage
 Stage III/IV vs. stage 0/I -0.12* -0.24** -0.22** -0.28** -0.30** -0.11 -0.25** -0.14* -0.14* -0.18* -0.18* -0.24**
 Stage II vs. stage 0/I -0.04 -0.06 -0.06 -0.05 -0.09* -0.02 -0.08* -0.03 -0.04 -0.04 -0.03 -0.01
Chemotherapy
 Yes vs. no -4.91* -4.63* -0.52 -3.20* 1.32 0.78 -4.10* -1.68 -1.56 -6.45** -3.57* -2.45*
Radiotherapy
 Yes vs. no 3.62* -1.56 1.63 3.57* -1.12 2.01 5.29** 2.84 -1.41 4.74* -1.03 1.03
Hormone therapy
 Yes vs. no 3.68* 0.57 1.68 -0.68 -0.82 0.94 4.52** 2.13 1.75 3.93* 0.34 1.08
Post-operative LOS -0.03 -0.06* -0.09** -0.12** -0.18** -0.02 -0.14** -0.11** -0.06* -0.04 -0.07* -0.08*
Preoperative QOL scores 0.39** 0.50** 0.61** 0.64** 0.57** 0.44** 0.48** 0.31** 0.42** 0.54** 0.48** 0.55**

#Values expressed as coefficients.

GQOL = global quality of life, PF = physical functioning, RF = role functioning, EF = emotional functioning, CF = cognitive functioning, SF = social functioning, BI = body image, SF = sexual functioning, SE = sexual enjoyment, FP = future perception, PCS = physical component summary, MCS = mental component summary, BCS = breast conserving surgery, MRM = modified radical mastectomy, TRAM = transverse rectus abdominis myocutaneous flap surgery (mastectomy with reconstruction), CCI = Charlson co-morbidity index, LOS = length of stay, QOL = quality of life.

*P<0.05,

**P<0.01