Changes in cytokines and chemokines based magnitude of viral rebound at 4 weeks post-treatment. (A) Association of Log10IP-10 and HCV Log10HCV viral RNA at 4 weeks post treatment. Mean (B) IP-10 (C) MIP-1β (D) IL-18 at baseline, weeks 1, 2, and 12 on SOF and RBV, and 4 weeks post-treatment in individuals with SVR, early and late viral rebound. ANOVA p-value <0.01 **, <0.05 *. 4 wks PT, 4 weeks post treatment; SVR, sustained virologic response. Early rebound is defined as the presence of ≥ 1000 IU/ml HCV RNA at 4 weeks post treatment.