Table 2.

Association of demographic and clinical characteristics with baseline cytokine/chemokine levels.

		IP-10 baseline		MCP-1 Baseline		MIP-1β Baseline		IL-18 Baseline
		β (SE)	Aβ (SE)	β (SE)	Aβ (SE)	β (SE)	Aβ (SE)	β (SE)	Aβ (SE)
Sex	Male	−0.03 (0.06)		−0.01 (0.03)		−0.06 (0.04)	---	0.06 (0.04)	--
	Female	REF		REF		REF	--	REF	--
Age	CONTINUOUS (1yr)	0.003 (0.003)		0.004(0.001)**	0.004 (0.001)*	0.005 (0.002)**	0.005 (0.002)*	−0.0002(0.002)
BMI	<30	REF		REF		REF		REF
	>30	0.02 (0.06)		−0.14 (0.13)		−0.11 (0.17)		0.01 (0.03)
Race	Asian	0.22 (0.28)		−0.13 (0.13)		0.11 (0.17)		−0.06(0.17)
	AA	0.14 (0.26)		0.04 (0.12)		0.07 (0.16)		0.14(0.15)
	AI/AN	REF		REF		REF		REF
	White	0.09 (0.24)		0.02 (0.11)		0.10 (0.15)		0.02(0.14)
Ethnicity	Hispanic	REF		REF		REF	--	REF
	Non-Hispanic	0.05 (0.11)		0.01 (0.05)		0.11 (0.07)	--	−0.06(0.06)
Creat clearance	CONTINUOUS	−0.001 (0.0009)		−0.0009 (0.0004)*	--	−0.001 (0.0005)*	--	0.0002(0.0005)
ALT	<1.5×ULN	REF	REF	REF	REF	REF	REF	REF
	≥ 1.5×ULN	0.22 (0.06)***	0.20 (0.06)***	0.05 (0.03)	0.04 (0.03)	0.07 (0.04)*	0.06 (0.04)
Genotype	GT2	0.09 (0.06)	--	−0.01 (0.03)		−0.01 (0.04)		0.02(0.03)
	GT3	REF	--	REF		REF		REF
Log10HCV RNA baseline	CONTINUOUS	−0.10 (0.03)**	−0.08 (0.03)*	−0.01 (0.02)		−0.002 (0.02)		−0.002(0.02)
Cirrhosis	Yes	REF		REF		REF		REF	REF
	No	−0.02 (0.06)		−0.03 (0.03)		0.03 (0.04)		−0.11(0.03)***	−0.11(0.03)***
IL28b genotype	CC	REF		REF		REF		REF	REF
	CT or TT	−0.02 (0.06)		0.002 (0.03)		−0.02 (0.04)		−0.07 (0.03)*	−0.06 (0.03)*

β = regression coefficient

Aβ = adjusted regression coefficient

SE = Standard Error

AA, African American; AI/AN, American Indian/Alaskan Native; ULN, upper limit of normal; HCV, Hepatitis C Virus; ALT, Alanine Aminotransferase; BMI, Body Mass Index; SVR, Sustained Virologic Response; GT2, genotype 2; GT3, genotype 3

^*p <0.05

^**p<0.01

^***p <0.001; calculated using the Students T distribution

“--” indicates variables that were dropped from the exploratory multivariable model