Table 3.
Correlates of sustained virologic response (SVR) in all patients treated with Sofosbuvir and Ribavirin.
| Relapse | SVR | P-value | OR (95% CI)a |
|||
|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | |||||
| Sex | Female | 14 (10.7%) | 31 (23.7%) | 0.14b | Reference | -- |
| Male | 39 (29.8%) | 47 (35.9%) | 0.54 (0.25, 1.15) | |||
| Log10IP10 baselined | 2.299 (0.299) | 2.398 (0.351) | 0.10c | 1.10 (0.99, 1.24) | -- | |
| Log10MIP1β baselined | 1.276 (0.208) | 1.334 (0.211) | 0.12c | 1.15 (0.97, 1.37) | 1.32 (1.08, 1.66)* | |
| Log10IP10 week 1d | 1.983 (0.233) | 2.084 (0.317) | 0.05c | 1.14 (1.00, 1.32) | -- | |
| Log10MIP1β week 1d | 1.116 (0.181) | 1.236 (0.230) | 0.002c | 1.32 (1.11, 1.61) | -- | |
| Log10IP10 week 2d | 1.950 (0.205) | 2.062 (0.336) | 0.02c | 1.16 (1.02, 1.35) | -- | |
| Log10MIP1β week 2d | 1.115 (0.151) | 1.235 (0.238) | <0.001c | 1.34 (1.12, 1.64) | -- | |
| Δ Log10MIP1β w0-1d | 0.160 (0.191) | 0.103 (0.184) | 0.10c | 0.85 (0.69, 1.03) | -- | |
| Δ Log10MIP1β w0-2d | 0.160 (0.184) | 0.099 (0.207) | 0.09c | 0.85 (0.70, 1.02) | 0.74 (0.58, 0.91)** | |
Variables meeting p-value <0.2 threshold for inclusion in initial multivariable analysis are reported. Percentages have been rounded and might not total 100.
a
Univariable (unadjusted) and multivariable (adjusted) ORs are presented.
b
P-values calculated by Fisher Exact Test
c
P-values calculated by independent sample t tests
d
Odds ratios were calculated per 0.1 unit increase
*
p <0.05
**
p<0.01
*** p <0.001; calculated in final multivariable model
“--” indicates variables that were dropped from the exploratory multivariable model
Mean and (SD) noted under Relapse and SVR for all continuous variables
Number and (Percentage) noted for all categorical variables