Table 5.
Relapse | SVR | P-value | OR (95% CI)a |
|||
---|---|---|---|---|---|---|
Unadjusted | Adjusted | |||||
Treatment Duration (wks) | 12 | 36 (46.2%) | 26 (33.3%) | 0.01b | 1 [Reference] 6.0 (1.73, 28.1) |
1 [Reference] 1.80 (1.59, 31.0)* |
16 | 3 (3.8%) | 13 (16.7%) | ||||
Clinical Trial | FUSION | 9 (11.5%) | 18 (23.1%) | 0.06b | 1 [Reference] 0.35 (0.13, 0.91) |
-- |
POSITRON | 30 (38.5%) | 21 (26.9%) | ||||
Log10HCV RNA baselinee | 6.064 (0.804) | 6.334 (0.750) | 0.13c | 1.58 (0.885, 2.966) | -- | |
Log10IP-10 baselined | 2.331 (0.262) | 2.459 (0.298) | 0.05c | 1.19 (1.01, 1.43) | -- | |
Log10MIP1β week 1d | 1.124 (0.166) | 1.215 (0.234) | 0.05c | 1.26 (1.00, 1.61) | 1.40 (1.08, 1.89)* | |
Log10IP-10 week 2d | 1.953 (0.173) | 2.062 (0.345) | 0.09c | 1.17 (0.99, 1.43) | -- | |
Log10MIP1β week 2d | 1.111 (0.132) | 1.202 (0.258) | 0.06c | 1.25 (1.00, 1.61) | -- | |
A Log10IP-10 w0-1d | 0.328 (0.227) | 0.402 (0.235) | 0.16c | 1.15 (0.95, 1.42) | 1.34 (1.06, 1.75)* |
Variables meeting p-value <0.2 threshold for inclusion in initial multivariable analysis are reported. Percentages have been rounded and might not total 100.
Univariable (unadjusted) and multivariable (adjusted) ORs are presented.
P-values calculated by Fisher Exact Test
P-values calculated by independent sample t tests
Odds ratios were calculated per 0.1 unit increase
Odds ratio was calculated per 1 log10 increase in viral load
“--” indicates variables that were dropped from the exploratory multivariable model
Mean and (SD) noted under Relapse and SVR for all continuous variables