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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Stroke. 2015 Aug 25;46(10):2926–2934. doi: 10.1161/STROKEAHA.115.010592

Figure 2. Treatment with anti-PD-L1 mAb, 4 h after MCAO, reduces infarct volume in male WT mice.

Figure 2

Infarct volume (% corrected contralateral structure) in cortex, striatum and hemisphere were determined by 2,3,5-triphenyltetrazolium chloride staining in isotype control-treated vs. anti-PD-L1 mAb-treated adult male WT mice. All mice underwent 1 hour of middle cerebral artery occlusion (MCAO), with treatments at 4 h after MCAO followed by 96 hours of reperfusion. A. Infarct volumes in anti-PD-L1 Ab- treated (n=23) male WT mice were significantly reduced compared to the isotype control-treated (n=21) mice. Values represent mean ± SEM. *p<0.05, **p<0.01. B. Representative cerebral sections showing localization of the ischemic lesions in anti-PD-L1 vs. isotype control mAb treated mice. Note-Three mice from the anti-PD-L1 mAb treated group were excluded due to hemorrhagic transformation.