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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nat Genet. 2015 Aug 31;47(10):1114–1120. doi: 10.1038/ng.3390

Figure 2.

Figure 2

Fitting region-specific LD heterogeneity of the genome using a sliding-window approach. Shown are the results for chromosome 22 from the UK10K-WGS data as example. LD score of each variant is defined as the sum of LD r2 between the target variant and all variants (including the target variant) within ±10Mb distance. For the GREML-LDMS analysis, the region-specific LD heterogeneity is fitted by segments with average length of 100Kb (the dots in blue) using a sliding window approach as described in Online Methods.