Figure 2.
SAH induces MMP-9 activation and activates astrocytes, oligodendrocyte precursors and microglia in white matter. (A) Representative gelatin zymography demonstrates that activity of MMP-9, but not MMP-2, increases in SAH compared to sham mice at 24 h after SAH induction. (B) Quantification of MMP-9 activity on gelatin zymography. **P < 0.01; Values are mean ± SD; n=3 for each. (C) Representative 3,3 diaminobenzidine (DAB) staining of glial fibrillary acid protein (GFAP), PDGFRα, and Iba-1 in the corpus callosum in sham and SAH mice at 24 hours (Scale bar = 100μm).