Table 3.
Estimate of the effect of fold change in gene expression on time to recurrence in the 30 patients
| Gene tested | p value | Hazard ratio | Lower limit of 95 % confidence interval for hazard ratio | Upper limit of 95 % confidence interval for hazard ratio |
|---|---|---|---|---|
| PITX2 | 0.0062 | 1.09 | 1.02 | 1.16 |
| TWIST1 | 0.005 | 1.71 | 1.18 | 2.48 |
| HSPB27 | 0.0139 | 6.66 | 1.47 | 30.18 |
| DUSP9 | 0.6 | 0.76 | 0.27 | 2.13 |
| ID1 | 0.99 | 0.99 | 0.85 | 1.17 |
| IGF | 0.61 | 1.11 | 0.73 | 1.69 |
| KRT19 | 0.79 | 1.04 | 0.78 | 1.38 |
| PDGFRL | 0.27 | 1.13 | 0.91 | 1.4 |
| PIR | 0.23 | 0.71 | 0.4 | 1.24 |
| S100A3 | 0.74 | 0.9 | 0.5 | 1.63 |
| SLAC2 | 0.44 | 0.85 | 0.58 | 1.27 |
| SNAIL1 | 0.2 | 0.44 | 0.13 | 1.53 |
All estimates are derived from single-variable models; in other words, fold change in only 1 gene has been included in each model. PITX2, TWIST1, and HSPB27 are statistically significantly related to time to recurrence