Fig. 5.

Central GLP-1R activation increases uptake of plasma TG-derived fatty acids and glucose by BAT in DIO mice. After 12 weeks of high-fat feeding, mice were treated for 5 days with i.c.v. exendin-4 (n = 10) or vehicle (control n = 6, pair-fed n = 9). After treatment, mice were injected with [³H]TO-labelled particles and [¹⁴C]DG. Plasma ³H activity (a) and ¹⁴C activity (c) were plotted relative to the injected dose. At 15 min after injection, organs were isolated and uptake of the ³H activity (b) and ¹⁴C activity (d) was determined. Values are mean ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 compared with control. ^† p < 0.05 and ^†† p < 0.01 compared with pair-fed control. White bars, control; black bars, exendin-4; grey bars, pair-fed control