Table 1.

Central GLP-1R activation decreases plasma TG and glucose levels in DIO mice

Variable	Control	Exendin-4	Pair-fed control
TG (mmol/l)
Start	0.7 ± 0.1	0.7 ± 0.1	0.6 ± 0.1
End	0.7 ± 0.5	0.5 ± 0.2*	0.6 ± 0.4
Glucose (mmol/l)
Start	11.3 ± 0.8	11.6 ± 1.1	11.4 ± 1.1
End	10.6 ± 0.9	4.5 ± 1.2***  , †††	7.4 ± 1.1***

After 12 weeks of high-fat feeding, mice were treated for 5 days with i.c.v. exendin-4 (n = 10) or vehicle (control n = 6, pair-fed n = 9). Blood was collected before and after treatment by tail bleeding after 4 h of fasting and plasma TG and glucose were determined

Values are mean ± SD

*p < 0.05 and ***p < 0.001 compared with baseline; ^††† p < 0.001 compared with pair-fed control