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. 2015 Jul 1;35(26):9638–9647. doi: 10.1523/JNEUROSCI.1740-15.2015

Figure 6.

Figure 6.

D2R abundance and signaling are reduced in the BLA of Lmo4gt/+ mice. A, BLA of WT (n = 6) and Lmo4gt/+ (n = 8) mice showed similar levels of Drd1 mRNA, but there was a striking reduction in Drd2 mRNA the BLA of Lmo4gt/+ mice compared with WT mice (*p = 0.04, two-tailed t test). B, C, Systemic administration of 1 mg/kg quinpirole increased P-Thr308 AKT immunoreactivity in the BLA of WT, but not Lmo4gt/+ mice (**p = 0.0045, two-tailed t test; n = 10–11 WT and n = 8–9 Lmo4gt/+ mice). D–F, BLA pyramidal neurons from Lmo4gt/+ mice are less responsive to dopamine. Representative traces for WT (D) and Lmo4gt/+ (E) neurons show action potentials evoked by 500 ms depolarizing current injection before and after bath application of dopamine. F, Time course for the effect of dopamine (DA) on spike firing. Data shown are mean ± SEM values derived from the current amplitude that elicited the maximal change in spike number relative to the baseline average, and are from 5 (WT) and 8 (Lmo4gt/+) cells (*p = 0.02, Bonferroni test).