Table 4.
Effect of coagulopathy on PHI after traumatic brain injury.
| Data type | Coagulation tests | Number of studies | Population size | P for test | Heterogeneity (I 2) | MD/OR (95% CI) |
|---|---|---|---|---|---|---|
| Continuous | PLT | 4 | 1003 | 0.06 | 0 | −7.24 [−14.77, 0.28] |
| PT | 2 | 630 | 0.56 | 90 | 0.25 [−0.60, 1.11] | |
| PTT | 4 | 1026 | 0.92 | 33 | 0.05 [−0.85, 0.94] | |
| D-dimer | 2 | 850 | 0.31 | 99 | 34.48 [−32.15, 101.11] | |
| Fg | 3 | 1044 | <0.001 | 0 | −0.26 [−0.39, −0.13] | |
| INR | 2 | 398 | 0.10 | 96 | 0.50 [−0.09, 1.08] | |
|
| ||||||
| Dichotomous | PLT | 4 | 1267 | <0.001 | 35 | 2.76 [1.62, 4.70] |
| PT | 5 | 1644 | <0.001 | 70 | 2.69 [1.55, 4.66] | |
| PTT | 4 | 1289 | 0.15 | 70 | 2.39 [0.72, 7.95] | |
| D-dimer | 3 | 1160 | <0.001 | 63 | 16.50 [4.94, 55.04] | |
| Fg | 3 | 1145 | <0.001 | 0 | 3.44 [2.37, 4.99] | |
| INR | 2 | 512 | <0.001 | 0 | 3.70 [1.11–6.29] | |
APTT: activated partial thromboplastin time; Fg: fibrinogen/fibrin; INR: international normalized ratio; PHI: progressive hemorrhagic injury; PLT: platelet counts; PT: prothrombin time; CI: confidence interval; MD: mean difference; OR: odds ratio.