Table 5.
Summary of the strength of coagulation tests in predicting PHI after traumatic brain injury.
| Data type | Coagulation test | Number of studies | Population size | Fisher's z | Weighted r | Range of effect size r |
|---|---|---|---|---|---|---|
| Continuous | PLT | 4 | 1003 | −0.07∗ | −0.06 | −0.13–−0.003 |
| PT | 2 | 630 | 0.10 | — | — | |
| PTT | 4 | 1026 | 0 | — | — | |
| D-dimer | 2 | 850 | 0.50∗ | 0.46 | 0.01–0.75 | |
| Fg | 3 | 1044 | −0.13∗ | −0.13 | −0.23–−0.04 | |
| INR | 2 | 398 | 0.52∗ | 0.47 | 0.36–0.59 | |
|
| ||||||
| Dichotomous | PLT | 4 | 1267 | 0.28∗ | 0.27 | 0.10–0.43 |
| PT | 5 | 1654 | 0.34∗ | 0.33 | 0.16–0.48 | |
| PTT | 4 | 1289 | 0.29 | — | — | |
| D-dimer | 3 | 1160 | 0.80∗ | 0.66 | 0.44–0.81 | |
| Fg | 3 | 1145 | 0.31∗ | 0.30 | 0.22–0.38 | |
| INR | 2 | 512 | 0.37∗ | 0.35 | 0.27–0.42 | |
APTT: activated partial thromboplastin time; Fg: fibrinogen/fibrin; INR: international normalized ratio; PHI: progressive hemorrhagic injury; PLT: platelet counts; PT: prothrombin time; ∗ P < 0.05.