TABLE 1.
Characteristics of DNA damage-regulated genes testeda
| Gene | H3K4me2 | ncRNA | Expression in: |
Role | |
|---|---|---|---|---|---|
| hos2Δ | set3Δ | ||||
| HUG1 | Promoter | Meiotic ORF (AS) | — | —* | Involved in Mec1 checkpoint |
| ERG5 | Promoter and 5′ ORF | XUT (AS) promoter, CUT (S) promoter | —* | Oxidation reduction and lipid metabolism | |
| GRE2 | Promoter and ORF | ncRNA (AS) whole ORF | —* | —* | Methylbutanal and glyoxal reductase |
a
The H3K4me2 column indicates if dimethylation of H3K4 was identified in a previous global survey (56) and its localization within the gene body (Saccharomyces Genome Database). The ncRNA column specifies the type, localization, and orientation, sense (S) or antisense (AS), of ncRNAs overlapping the genes tested (54, 55, 57, 58). The hos2Δ and set3Δ columns show if expression was downregulated (—) in the corresponding null strains (60) and whether the change was statistically significant (*).