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. 2015 Oct 1;9:382. doi: 10.3389/fncel.2015.00382

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Copyright © 2015 Findlay, Hamilton and Ashford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BACE1 overexpression has no effect on ATP-linked, maximal or leak mitochondrial oxygen consumption. (A) Modified mitochondrial stress temporal profile for EV and BACE1 SH-SY5Y cells showing the effects on the percentage change in normalized OCR of the sequential addition of 1 μM oligomycin (oligo) and 2 μM rotenone and antimycin (Rot + Ant). (B–D) BACE1 overexpression had no effect on ATP-linked OCR (B), on the OCR required to maintain the mitochondrial leak (C) or the non-mitochondrial OCR (D) compared to EV cells (n = 8). (E) Temporal profile showing the normalized baseline OCR for EV and BACE1 cells and the maximal OCR (reserve capacity) attained following addition of 0.2 μM carboyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP). (F) BACE1 overexpression has no effect on the percentage OCR increase following FCCP addition compared to EV cells (n = 9–10). Values are means ± SEM.