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. 2015 Oct 1;5:14726. doi: 10.1038/srep14726

Table 2. Results from structural equation modelling: total, direct and indirect effects (standardized regression coefficients and 95% CIs) of the weighted polygenic risk score on anthropometric traits.

  DILGOM (N = 4632) FinnTwin12 (N = 1231) All (meta-analysis)
Std. β (95% CI) Std. β (95% CI) Std. β (95% CI)
Mediation model 1
 Total effect of weighted PRS on BMIa 0.171 (0.143, 0.199)* 0.149 (0.088, 0.210)* 0.167 (0.142, 0.192)*
 Direct effect of weighted PRS on BMIb 0.139 (0.112, 0.166)* 0.149 (0.088, 0.210)* 0.141 (0.116, 0.166)*
 Indirect effect (via uncontrolled eating) of weighted PRS on BMIc 0.032 (0.021, 0.043)* 0.000 (−0.001, 0.001) 0.026 (0.016, 0.036)*
Mediation model 2
 Total effect of weighted PRS on WCa 0.136 (0.109, 0.162)* 0.139 (0.076, 0.202)* 0.136 (0.113, 0.160)*
 Direct effect of weighted PRS on WCb 0.106 (0.081, 0.131)* 0.138 (0.075, 0.202)* 0.110 (0.087, 0.134)*
 Indirect effect (via uncontrolled eating) of weighted PRS on WCc 0.030 (0.020, 0.040)* 0.001 (-0.003, 0.004) 0.026 (0.016, 0.036)*
Mediation model 3
 Total effect of weighted PRS on BMIa 0.171 (0.143, 0.199)* 0.149 (0.088, 0.209)* 0.167 (0.142, 0.192)*
 Direct effect of weighted PRS on BMIb 0.148 (0.121, 0.175)* 0.134 (0.073, 0.195)* 0.146 (0.121, 0.171)*
 Indirect effect (via emotional eating) of weighted PRS on BMIc 0.022 (0.013, 0.032)* 0.015 (0.000, 0.029)‡ 0.021 (0.013, 0.029)*
Mediation model 4
 Total effect of weighted PRS on WCa 0.135 (0.109, 0.162)* 0.140 (0.077, 0.203)* 0.136 (0.112, 0.159)*
 Direct effect of weighted PRS on WCb 0.115 (0.090, 0.140)* 0.127 (0.064, 0.190)* 0.117 (0.093, 0.140)*
 Indirect effect (via emotional eating) of weighted PRS on WCc 0.020 (0.011, 0.029)* 0.013 (0.000, 0.026)‡ 0.019 (0.011, 0.027)*

Note. All models were adjusted for age and sex in both cohorts and clustering was taken into account in all analyses performed in FinnTwin12. *P < 0.001; †P < 0.01, ‡P < 0.05.

aTotal effect  =  c + ab in Figs 1 and 2;

bDirect effect  =  c in Figs 1 and 2;

cIndirect effect  =  ab in Figs 1 and 2. PRS = Polygenic risk score; BMI = Body mass index; WC = Waist circumference.