Table 1. Summary of oncolytic HSVs discussed in the text.
| Virus | Deletions | Foreign gene/promoter insertion | References |
|---|---|---|---|
| C134 | Deletions in both copies of γ134.5 gene | IRS1 gene under control of an HCMV immediate early promoter | 20,74 |
| d12.CALP | ICP4 deletion | Calponin promoter | |
| G207 | Deletions in both copies of γ134.5 gene and disabling lacZ insertion within ICP6 gene | LacZ | 8,20,22,23,41,42,72 |
| G47Δ | Deletions of the γ134.5 and α47 genes and a disabling lacZ insertion within ICP6 gene | LacZ | 29,30 |
| hrR3 | In-frame insertion of the bacterial lacZ gene within ICP6 | LacZ | 22,23 |
| HSV1716 | Deletions in both copies of γ134.5 gene | None | 17,68 |
| M002 | Deletions in both copies of γ134.5 gene | Murine IL-12 under the transcriptional control of the murine early-growth response-1 promoter (Egr-1) | 13,45,60,70,72 |
| NV1020 | Deletion in thymidine kinase (tk) locus and across the joining region of the long and short components of the HSV-1 genome | HSV-1 DNA fragment encoding the tk gene fused to the α gene promoter | 41,43 |
| NV1066 | Same NV1020 | Enhanced GFP, CMV promoter | 9,43 |
| oHSV-MDK-34.5 | Deletions of ICP6 and ICP34.5 | ICP34.5 expression driven by the midkine promoter | 24 |
| rRp450 | Deletion of ICP6 | Rat CYP2B1 | 44,49,50 |
| rQNestin-34.5 | Deletions in γ134.5 gene and in-frame gene-disrupting insertion of GFP within ICP6 gene | ICP34.5 under control of a synthetic nestin promoter | 11 |
| rQT3 | Deletions in ICP6 and γ134.5 | Tissue inhibitor of metalloproteinases 3, HSV-1 immediate early 4/5 promoter | 11 |
CMV, cytomegalovirus; GFP, green fluorescent protein; HCMV, human cytomegalovirus; HSV, herpes simplex virus.