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. 2015 Oct 1;5:14816. doi: 10.1038/srep14816

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Copyright © 2015, Macmillan Publishers Limited

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Mice were injected with 1 or 2 mg/kg TBBt or 2 or 5 mg/kg emodin via i.p. before I/R injury. After 24-h reperfusion, blood was collected for the measurement of BUN (A) and creatinine (B). (C) Mice were injected with 2 mg/kg TBBt or 5 mg/kg emodin, and kidney tissues were collected 24 h after reperfusion. Tissues were stained with hematoxylin and eosin (H&E, ×200) and periodic acid Schiff (PAS, ×200 or ×400) for light microscopic analysis. Bar = 250 μm. Histopathologic scoring (D) and quantification of necrotic area (E) were performed in a blind method. Values are mean ± SEM (n = 6 mice per group). ^**p < 0.01 vs. sham; ^##p < 0.01 vs. VEH. VEH, vehicle; TBBt-1, 1 mg/kg TBBt; TBBt-2, 2 mg/kg TBBt; Emo-2, emodin 2 mg/kg; Emo-5, emodin 5 mg/kg.