Table 2.

Brain regions showing significant differences in RD and AD values in patients with RLS as compared to healthy controls

Region	Size (mm3)	Maximum P (10−x)	Corrected Cluster wise P	X	Y	Z
Regions with significant higher RD values
Pons	54	2.46	<0.0001	94	102	41
Cerebellum left	60	2.66	<0.0001	100	48	32
Cerebellum right	155	2.86	<0.0001	59	49	34
Subcortical right	89	3.97	<0.0001	31	113	96
Subcortical right	38	1.97	<0.0001	32	86	106
Subcortical right	7	1.85	<0.0001	42	126	92
Subcortical left	14	1.99	<0.0001	102	98	128
Parietal right	67	2.59	<0.0001	63	77	77
Callosal body	15	2.07	<0.0001	70	79	90
Regions with significant higher AD values
Crus cerebri right	37	−3.18	<0.0001	103	117	62
Pallidum right	16	−2.27	<0.0001	75	138	61
Cerebellum right	35	−2.35	<0.0001	44	72	37
Subcortical right	58	−2.09	<0.0001	133	92	78

AD, Axial diffusivity; RD, Radial diffusivity; RLS, Restless legs syndrome.

The P-values given are clusterwise P-values. Several connected voxels with significant changes were automatically searched and merged into one cluster. The size of each cluster is given in mm³. X, Y, and Z coordinates are presented in MNI 152 space.