Table 3.
Neural substrates of BIS score
| Anatomic region | mm3 | x | y | z | t-value | β-weight |
|---|---|---|---|---|---|---|
| R anterior cingulate1 | 1801 | 14 | 39 | 0 | 3.93 | 0.212 |
| R precentral gyrus | 408 | 58 | 3 | 15 | 4.11 | 0.182 |
| R middle frontal gyrus | 402 | 28 | 63 | −6 | 3.72 | 0.222 |
| R superior frontal gyrus | 179 | 6 | 59 | 30 | 3.79 | 0.44 |
| L insula | 235 | −44 | 8 | 3 | 3.79 | 0.34 |
Regions where BIS score negatively correlated with grey matter volume, adjusting for age, gender, MMSE, scanner type, and total intracranial volume (TIV) (corrected for family-wise error (FWE) across the whole brain at a significance level of P < 0.05).
1
Region remains significant when diagnostic group is entered into the model.
2
Region remains a significant independent predictor of BIS score when all peaks modeled together in a regression analysis.