Table 3.

McDonald MRI criteria for demonstration of DIS (Polman et al. 2011)

DIS can be demonstrated by ≥ 1 T2 lesions1 in at least 2 of the 4 area of the CNS
Periventricular
Juxtacortical
Infratentorial
Spinal cord2

MRI, magnetic resonance imaging; DIS, lesion dissemination in space; CNS, central nervous system.

Based on Swanton et al. 2006, 2007.

Adapted from Polman et al. (2011).

¹Gadolinium enhancement of lesions is not required for DIS.

²If a subject has a brainstem or spinal cord syndrome, the symptomatic lesions are excluded from the Criteria and do not contribute to lesion count.