Table 3.
Top 20-ranked repositioned drug candidates. NCT**: SCZ drugs from clinical trials. PMID**: SCZ drugs from biomedical literature.
| R | Drug | Evidence | R | Drug | Evidence |
|---|---|---|---|---|---|
| 1 | risperidone | FDA-approved | 11 | memantine |
NCT02001103 NCT00757978 NCT00097942 |
| 2 | methylphenidate | NCT00794040 | 12 | buspirone | NCT00178971 |
| 3 | quetiapine | FDA-approved | 13 | paliperidone | FDA-approved |
| 4 | citalopram |
NCT00893256 NCT00047450 NCT01032083 NCT01032083 |
14 | haloperidol | FDA-approved |
| 5 | olanzapine | FDA-approved | 15 | lithium |
NCT00202306 NCT00183443 NCT00202293 |
| 6 | sertraline |
NCT00169988, NCT00531518 |
16 | amantadine |
NCT00999505 NCT00975611 NCT00401973 |
| 7 | aripiprazole | FDA-approved | 17 | levodopa | NCT01636037 |
| 8 | ziprasidone | FDA-approved | 18 | atomoxetine |
NCT00420498 NCT00222794 NCT00488163 NCT00628394 NCT00161031, NCT00089869 |
| 9 | clozapine | FDA-approved | 19 | clomipramine | PMID9659874 PMID7635998 PMID7903293 |
| 10 | valproic acid |
NCT00194025 NCT01094249 NCT02011750 |
20 | prednisone | PMID17245324 PMID23738211 |