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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Theor Biol. 2014 Apr 13;355:170–184. doi: 10.1016/j.jtbi.2014.02.042

Figure 4. The three dynamic regimes.

Figure 4

Regime 1: first successful type-2 cell (arrow) arises in the first premalignant clone, Γ = 0.055. Regime 2: several premalignant clones are present at the time of the first successful type-2 cell, Γ = 54.47. Regime 3: a large number of small premalignant clones are present by the time of the first successful type-2 cell, Γ = 5.45 × 104. Simulations obtained with parameter values as in Figure 5.