Table 1. Ten new CAD loci.
| Association model | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Additive | Recessive | |||||||||||
| Lead variant | Locus name | Chr. | A1/A2 | Effect allele (A1) freq. | Imputation quality | I2 | Heterogeneity P | n studies | OR (95% CI) | P | OR (95% CI) | P |
| rs17087335 | REST-NOA1 | 4 | T/G | 0.21 | 0.99 | 0.20 | 0.11 | 48 | 1.06 (1.04-1.09) | 4.60E-08 | 1.11 (1.05-1.17) | 3.30E-04 |
| rs3918226 | NOS3 | 7 | T/C | 0.06 | 0.78 | 0.15 | 0.19 | 45 | 1.14 (1.09-1.19) | 1.70E-09 | 1.26 (0.99-1.60) | 5.96E-02 |
| rs10840293 | SWAP70 | 11 | A/G | 0.55 | 0.94 | 0.17 | 0.16 | 47 | 1.06 (1.04-1.08) | 1.30E-08 | 1.05 (1.02-1.09) | 1.51E-03 |
| rs56062135 | SMAD3 | 15 | C/T | 0.79 | 0.98 | 0.00 | 0.67 | 46 | 1.07 (1.05-1.10) | 4.50E-09 | 1.17 (1.10-1.25) | 8.88E-07 |
| rs8042271 | MFGE8-ABHD2 | 15 | G/A | 0.9 | 0.93 | 0.16 | 0.19 | 46 | 1.10 (1.06-1.14) | 3.70E-08 | 1.25 (1.13-1.37) | 7.27E-06 |
| rs7212798 | BCAS3 | 17 | C/T | 0.15 | 0.95 | 0.14 | 0.21 | 48 | 1.08 (1.05-1.11) | 1.90E-08 | 1.17 (1.07-1.28) | 6.12E-04 |
| rs663129 | PMAIP1-MC4R | 18 | A/G | 0.26 | 1.00 | 0.00 | 0.6 | 47 | 1.06 (1.04-1.08) | 3.20E-08 | 1.11 (1.06-1.17) | 7.15E-06 |
| rs180803 | POM121L9P-ADORA2A | 22 | G/T | 0.97 | 0.86 | 0.00 | 0.67 | 41 | 1.20 (1.13-1.27) | 1.60E-10 | N/A | N/A |
| rs11830157 | KSR2 | 12 | G/T | 0.36 | 0.99 | 0.14 | 0.22 | 42 | 1.04 (1.02-1.06) | 3.90E-04 | 1.12 (1.08-1.16) | 2.12E-09 |
| rs12976411 | ZNF507-LOC400684 | 19 | T/A | 0.09 | 0.93 | 0.50 | 5.09E-04 | 34 | 0.95 (0.92-0.99) | 9.10E-03 | 0.67 (0.60-0.74) | 1.18E-14 |
Association results are presented for two inheritance models; results in bold text indicate the discovery association model. P values have been adjusted for over-dispersion following meta-analysis. Heterogeneity P values are for the respective discovery association model. Chr., chromosome; A1, effect allele; A2, non-effect allele; freq., frequency; I2, heterogeneity inconsistency index; OR, odds ratio; CI, confidence interval; N/A, not available due to insufficient numbers (<60%) of studies for reliable results. The n studies column shows the number of studies participated in the discovery result where up to 48 studies participated in the additive model and up to 43 studies in the recessive model meta-analysis.