Table 4.
Summary of primary and sensitivity analyses
| Outcome | Primary analysis | Sensitivity analyses | ||
|---|---|---|---|---|
| Excluding ‘lower’ quality studies [8, 12–15] a | Excluding imputed data [10] b | Excluding studies that did not use electrocautery in conventional [8, 15–18] c | ||
| Operating Time (min) | −29.13 (−36.73, −21.53) | −22.72 (−31.75, −13.68) | −30.34 (−38.13, −22.54) | −28.95 (−38.44, −19.35) |
| (MD [95 %CI]) | ||||
| Intraoperative Blood Loss (mL) | −45.54 (−72.20, −18.89) | −42.48 (−67.97, −16.99) | Identical to primary analysis | −42.48 (−67.97, −16.99) |
| (MD [95 %CI]) | ||||
| Post-Operative Pain (VAS) | −1.33 (−1.99, −0.67) | −1.33 (−1.99, −0.67) | −1.33 (−1.99, −0.67) | |
| (MD [95 %CI]) | ||||
| Length of Stay (days) | −0.68 (−1.16, −0.20) | −0.71 (−1.24, −0.18) | −0.59 (−1.21, 0.02) | |
| (MD [95 %CI]) | ||||
| Drainage Volume (mL) | −29.38 (−52.46, −6.30) | −29.38 (−52.46, −6.30) | −29.38 (−52.46, −6.30) | |
| (MD [95 %CI]) | ||||
| Hemorrhage require surgery | 0.68 (0.19, 2.46) | 0.78 (0.19, 3.18) | 0.32 (0.05, 2.01) | |
| (RR [95 %CI]) | ||||
| Transient Hypocalcemia | 0.60 (0.44, 0.82) | 0.67 (0.45, 1.00) | 0.54 (0.37, 0.78) | |
| (RR [95 %CI]) | ||||
| Persistent Hypocalcemia | 0.35 (0.07, 1.91) | 0.90 (0.06, 14.25) | Too few studies to inform (<2) | |
| (RR [95 %CI]) | ||||
| Transient RLN Paresis | 0.64 (0.28, 1.44) | 0.57 (0.23, 1.43) | 0.43 (0.16, 1.14) | |
| (RR [95 %CI]) | ||||
| Persistent RLN Paresis | 0.33 (0.01, 8.03) | 0.33 (0.01, 8.03) | Too few studies to inform (<2) | |
| (RR [95 %CI]) | ||||
| Wound Seroma | 0.57 (0.12, 2.65) | 0.57 (0.12, 2.65) | Too few studies to inform (<2) | |
| (RR [95 %CI]) | ||||
CI Confidence Interval, LOS Length of Stay, MD Mean Difference, RR Relative Risk, VAS Visual Analog Scale, min minutes, mL milliliters
aLower quality study defined as: ≥ 4 “unclear” OR one “No” listed in any risk of bias assessment category: Cannizzaro [12], Pons [8], Sista [13], Duan [14], Soroush [15]
bMiccoli [10]
cDi Renzo [14], Docimo [16], Materazzi [17], Pons [8], Soroush [15]