Fig. 4.
Fibrotic encapsulation of the grafted islets visualized by αSMA expressing tissue one week post transplantation. a Control section with a large portion of αSMA+ (red) fibrotic tissue surrounding the islets (blue). b In the presence of MSC (green) one-week post transplantation only a moderate fibrotic encapsulation (αSMA, red) could be seen surrounding the islets (blue). c Tissue in panel B without imaged MSC. d Quantification showed significantly lower levels (*p < 0.05) of fibrotic tissue surrounding the graft at 7 days post transplantation in the presence of MSC as measured by total expression of αSMA. Bars = 100 um