Table 6.

Anti-inflammatory activity of 80 % methanol extract of the rhizomes of Rumex abyssinicus on carrageenan-induced mice paw edema following oral administration

Group	Mean change in the paw volume (ml)
	Basal	1 h	2 h	3 h	4 h
Control	0.50 ± 0.04	0.61 ± 0.02	0.7 ± 0.03	0.69 ± 0.04	0.65 ± 0.03
Extract (250 mg/kg)	0.50 ± 0.02	0.60 ± 0.03 (1.64 %)	0.58 ± 0.04 (17 %)	0.55 ± 0.02a1 (20.29 %)	0.51 ± 0.02a2 (21.54 %)
Extract (500 mg/kg)	0.50 ± 0.03	0.55 ± 0.02 (9.84 %)	0.47 ± 0.04a3 (32.86 %)	0.44 ± 0.02a3 (36.23 %)	0.30 ± 0.03a3c3 (53.85 %)
Extract (750 mg/kg)	0.51 ± 0.01	0.48 ± 0.04 (21.31 %)	0.43 ± 0.02a3,c1 (38.57 %)	0.40 ± 0.04a3,c2 (42.03 %)	0.25 ± 0.02a3c3 (61.54 %)
Indomethacin (10 mg/kg)	0.53 ± 0.03	0.48 ± 0.03 (24.6 %)	0.35 ± .02a3c3 (50 %)	0.24 ± 0.02a3c3 (65 %)	0.10 ± 0.02a3c3 (84.6 %)

n = 6 animals in each group; Values are expressed as mean ± SEM, with inhibition deppicted in parenthesis; data were analyzed by one way ANOVA followed by tuckey post hoc test;; ^aagainst control, ^cagainst 250 mg/kg; ¹ p < 0.05, ² p < 0.01, ³ p < 0.001