Table 2.

Blood cells counts of 4 month-old B6/129, B6 and 129 mice

	B6/129 mice
	K-Ras+/+ (n = 10)	K-Ras+/V14I (n = 15)	K-RasV14I (n = 10)	p value +/+ vs +/V14I		p value +/+ vs V14I
WBC (109/l)	9.76 ± 3.12	12.16 ± 2.15	16.77 ± 5.57	0.0825	NS	0.0100	**
LYM (109/l)	8.43 ± 2.91	8.53 ± 1.86	7.37 ± 2.94	0.9363	NS	0.5148	NS
MID (109/l)	0.43 ± 0.26	0.53 ± 0.31	0.83 ± 0.87	0.5316	NS	0.3306	NS
GRA (109/l)	0.81 ± 0.39	2.28 ± 2.14	8.87 ± 4.97	0.0747	NS	0.0122	*
RBC (1012/l)	9.36 ± 0.33	9.07 ± 1.47	6.21 ± 2.08	0.1441	NS	0.0010	***
PLT (109/l)	714 ± 265	547.7 ± 276	344.5 ± 129	0.2557	NS	0.1009	NS
	B6 mice (F5)
	K-Ras+/+ (n = 6)		K-Ras+/V14I (n = 11)	p value +/+ vs +/V14I
WBC (109/l)	9.96 ± 0.14		13.80 ± 5.56	0.1413	NS
LYM (109/l)	8.42 ± 2.96		10.71 ± 5.36	0.3505	NS
MID (109/l)	0.38 ± 0.44		0.38 ± 0.18	0.9969	NS
GRA (109/l)	1.17 ± 0.41		2.71 ± 1.56	0.0089	**
RBC (1012/l)	10.62 ± 1.03		8.38 ± 1.26	0.0022	**
PLT (109/l)	959.6 ± 425.1		230.0 ± 163.3	0.0142	*
	129 mice (F5)
	K-Ras+/+ (n = 9)	K-Ras+/V14I (n = 10)	K-RasV14I (n = 6)	p value +/+ vs +/V14I		p value+/+ vs V14I
WBC (109/l)	7.33 ± 2.19	9.07 ± 2.76	15.64 ± 7.04	0.1510	NS	0.0332	*
LYM (109/l)	6.13 ± 1.73	7.57 ± 2.78	8.84 ± 3.83	0.1995	NS	0.1530	NS
MID (109/l)	0.19 ± 0.12	0.29 ± 0.15	0.90 ± 0.74	0.1369	NS	0.0981	NS
GRA (109/l)	1.02 ± 0.69	1.21 ± 0.59	6.04 ± 5.17	0.5173	NS	0.0630	NS
RBC (1012/l)	10.43 ± 1.68	10.85 ± 0.88	10.36 ± 0.67	0.9241	NS	0.4952	NS
PLT (109/l)	305.0 ± 153.7	363.89 ± 190.7	182.67 ± 147	0.3721	NS	0.2247	NS

WBC: white blood cells; LYM: lymphocytes; MID: monocytes and some eosinophiles; GRA: granulocytes; RBD: red blood cells; PLT: platelets. Numbers shown are the media ± SD. Statistical significance was assessed by 2-tailed Student's t-test.

*P < 0.05; **P < 0.01;

***P <0.001; NS, not significant.

Note, the B6/129 data was previously published,¹⁹ included here for comparison.