Table 2.
B. Detailed descriptions of injection site reactions
| CTCAE Grade, Number of Events, (Number of Patients) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dose (μg/peptide) Adverse Event |
Grade 1 |
Grade 2 |
Grade 3 |
Grade 4 |
||||||||||||
| 50 | 100 | 250 | 500 | 50 | 100 | 250 | 500 | 50 | 100 | 250 | 500 | 50 | 100 | 250 | 500 | |
| Injection site reaction, immediate | 23 (6) | 24 (6) | 18 (6) | 11 (6) | 1 (1) | – | 6 (3) | 11 (6) | – | – | – | – | – | – | – | – |
| Pain | – | – | – | – | 1 (1) | – | 6 (3) | 11 (6) | – | – | – | – | – | – | – | – |
| Redness | 24 (6) | 23 (6) | 24 (6) | 22 (6) | – | – | – | – | – | – | – | – | – | – | – | – |
| Swelling | 2 (1) | 7 (2) | 1 (1) | 8 (4) | – | – | – | – | – | – | – | – | – | – | – | – |
| Welt | 7 (4) | 16 (5) | 22 (6) | 21 (6) | – | – | – | – | – | – | – | – | – | – | – | – |
| Tenderness | – | – | – | 1(1) | – | – | – | – | – | – | – | – | – | – | – | – |
| Itching | 13(5) | 13(5) | 11(5) | 9(4) | – | – | – | – | – | – | – | – | – | – | – | – |
| Burning | – | 1(1) | 1(1) | 5(4) | – | – | – | – | – | – | – | – | – | – | – | – |
| Warmness | – | 1(1) | 1(1) | – | – | – | – | – | – | – | – | – | – | – | – | |
| Injections interaction, delayed | 5(4) | 4(3) | 3(3) | 4(3) | 1(1) | 1(1) | 3(1) | 5(4) | – | – | – | – | – | – | – | – |
| Pain | – | – | – | 1(1) | 1(1) | 3(1) | 5(4) | – | – | – | – | – | – | – | – | |
| Redness | 5(4) | 2(2) | 5(3) | 3(3) | – | – | – | – | – | – | – | – | – | – | – | – |
| Swelling | 5(4) | 2(2) | 2(2) | 5(5) | – | – | – | – | – | – | – | – | – | – | – | – |
| Welt | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| Tenderness | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| Itching | 1(1) | 2(2) | 3(3) | 4(4) | – | – | – | – | – | – | – | – | – | – | – | – |
| Burning | – | 2(1) | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Warmness | – | – | 1(1) | – | – | – | – | – | – | – | – | – | – | – | ||