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. 2015 May 26;4(11):e1027469. doi: 10.1080/2162402X.2015.1027469

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Hanren Dai, Wenying Zhang, Xiaolei Li, Qingwang Han, Yelei Guo, Yajing Zhang, Yao Wang, Chunmeng Wang, Fengxia Shi, Yan Zhang, Meixia Chen, Kaichao Feng, Quanshun Wang, Hongli Zhu, Xiaobing Fu, Suxia Li, and Weidong Han

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — CD19-specific cytotoxic activity of CART-19 cells. (A) CART-19 cells were produced by activating peripheral-blood mononuclear cells (PBMC) with anti-CD3 antibody OKT3 on day 0 and transducing T cells on days 2 and 3. After 10–12 d of culture, cells were released for infusion. (B) Cytotoxic activity of mock-transfected and CART-19 cells against primary CD19⁺ B-ALL blasts, evaluated in a 6 h CFSE-staining assay; results are shown at an effector:target (E:T) ratio of 20:1. (C) Cytotoxic activity of non-transfected, mock-transfected and CART-19 cells obtained from all nine patients against CD19⁺ Raji and NALM6 and CD19⁻ K562 cell lines. The data are presented as the mean of triplicate values from each patients, and error bars represent SD. Arrows indicated the date of lentivirus transfection.