Figure 3.

Effect of atorvastatin on caspase-3, p-eIF2α and PERK protein expression in infarcted brain tissue of rats with cerebral ischemia/reperfusion injury (western blot assay).

Protein expression levels were expressed as the optical density ratio of caspase-3, p-eIF2α and PERK to β-actin. Data are represented as the mean ± SD (n = 15 rats per group). The difference among groups was compared using one-way analysis of variance followed by the least significant difference test. **P < 0.01, vs. I; #P < 0.05, vs. II. PERK: Protein kinase-like endoplasmic reticulum kinase; p-eIF2α: phosphorylated eukaryotic initiation factor 2α; I: sham group; II: atorvastatin + salubrinal group; III: ischemia/reperfusion group; IV: atorvastatin group.