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. 2014 Jan 17;4(2):135–140. doi: 10.1016/j.apsb.2013.12.007

Figure 4.

Figure 4

Inhibition of recombinant DPP8/9 and DPP4 activities by UAMC00132 and Sitagliptin. Chemical structure of UAMC00132 (A) and sitagliptin (B). (C) The DPP8/9 and DPP4 inhibitory activities of sitagliptin and UAMC00132. In DPP8/9 inhibition assays, 30 ng/mL purified DPP8 protein or 20 ng/mL purified DPP9 protein and 0.2 mmol/L substrate were used, and in DPP4 inhibition assay, 1 mU/mL DPP4 protein and 0.1 mmol/L substrate were used. The result was presented as the percentage of enzyme activity inhibition.