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. 2015 Sep 24;10:5981–5993. doi: 10.2147/IJN.S90104

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© 2015 Heo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vivo tumor volume and animal survival after intratumoral (IT) injection of an anticancer drug (HA/PTX) and immune modulators (PCNs with or without PINs).

Notes: (A) Time course of tumor growth (n=12) after the injections (filled arrow: HA/PTX; unfilled arrow: PLGA NPs) of either PBS, HA alone, or HA/PTX with or without PLGA NPs (*P<0.05 vs the PCNs group). (B) Kaplan–Meier survival plot of the mice inoculated with cancer cells and then subjected to intratumoral injection of the indicated materials. Red and blue arrows, represent the points of anticancer drug, and immune modulators, respectively.

Abbreviations: HA, hyaluronic acid; PTX, paclitaxel; PLGA, poly(lactic-co-glycolic acid); NP, nanoparticle; PBS, phosphate-buffered saline; vs, versus.