Table 1.
Characterization of immunomodulatory PLGA NPs
| Formulation | Mean diameter ± SD (nm) | Zeta potential ± SD (mV) | Loading amount of CpG ODN ± SD (μg/mg) | Loading amount of siRNA ± SD (μg/mg) | Polydispersity index |
|---|---|---|---|---|---|
| PCNs | 142.9±13.7 | −24.21±1.46 | 4.7±0.32a | – | 0.17±0.02 |
| PINs | 151.0±14.1 | −17.99±1.85 | – | 3.69±0.69a | 0.13±0.02 |
Notes:
a
Loading amount per 1 mg of PLGA NPs. Values are presented as the mean ± SD (n=3).
Abbreviations: PLGA, poly(lactic-co-glycolic acid); NP, nanoparticle; SD, standard deviation; CpG ODN, cytosine–phosphate–guanosine oligodeoxynucleotides; siRNA, small interfering RNA.