Table 1.
Composition of LNPs expressed as mol%
| Lipid | Names of LNPs
|
|||||
|---|---|---|---|---|---|---|
| PE-PEG-LNP | A/PE-PEG-LNP | Chol-PCL-LNP | A/Chol-PCL-LNP | DM-PCL-LNP | A/DM-PCL-LNP | |
| DSPE-PEG2000 | 5 | 4.5 | – | – | – | – |
| DSPE-PEG2000-angiopep | – | 0.5 | – | 0.5 | – | 0.5 |
| Chol-PCL | – | – | 5.0 | 4.5 | – | – |
| DM-PCL | – | – | – | – | 5.0 | 4.5 |
| Cholesterol | 35 | 35 | 35 | 35 | 35 | 35 |
| DOTAP | 25 | 25 | 25 | 25 | 25 | 25 |
| POPC | 19.5 | 19.5 | 19.5 | 19.5 | 19.5 | 19.5 |
| DODAP | 15 | 15 | 15 | 15 | 15 | 15 |
| DOPE-RhB | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
Abbreviations: DSPE-PEG2000, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-(polyethylene glycol)2000; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; DOTAP, 1,2-dioleoyl-3-trimethylammonium-propane; DODAP, 1,2-dioleoyl-3-dimethylammonium-propane; DOPE-RhB, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl); LNPs, lipid nanoparticles; PEG, poly(ethylene glycol); PCL, PEGylated cleavable lipopeptide; RhB, Rhodamine B; Chol, cholesterol; DM, dimyristoyl.