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. 2015 Sep 21;10:5881–5894. doi: 10.2147/IJN.S84273

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© 2015 Tai et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Simvastatin-induced ALP activity and mineralization was reduced by cytoskeletal alteration agents.

Notes: Disrupting actin filament organization or decreasing cell rigidity reduced simvastatin-induced ALP activity on Day 3 (A) and mineralization on Day 5 (B) after treatment. The results are the mean values of three independent measurements, error bars: SEM. **P<0.01 vs control; ^##P<0.01 vs SIM (1 µM).

Abbreviations: SIM, simvastatin; Bleb, blebbistatin; CD, cytochalasin D; ALP, alkaline phosphatase; SEM, standard error of the mean.